The Sisters of the Holy Spirit and Mary Immaculate collaborate with, support, sponsor, or belong to the following groups and organizations:

Catholic Worker House
A ministry to provide care, comfort, and support to people who are homeless in San Antonio

Crosspoint, Inc.
Re-entry program for federal prisoners

Habitat for Humanity
Nonprofit housing organization to build decent and affordable homes without interest or profit

Healy-Murphy Center
Healy-Murphy center is a program of the Sisters of the Holy Spirit whose mission is to provide compassionate service to youth-in-crisis by focusing on individualized education in a non-traditional setting, early childhood development and essential support services.

Leadership Conference of Women Religious
Association of the leaders of congregations of Catholic women religious in the United States, organized to further the Gospel in today's world

Merced Housing
Creates and strengthens healthy communities by providing quality, affordable, and service-enriched housing for the economically poor in Texas

Socially Responsible Investment Coalition (SRIC)
A nonprofit organization that works to influence corporations toward social responsibilty.

USCCB Social Justice and Human Development Committee
Guides the work of the United States bishops on domestic issues (poverty, health care, housing, civil rights, nutrition, and agriculture) with special attention to their religious and moral aspects

Union of Superiors General
Organization of superiors representing congregations of women religious throughout the world